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| Synthesis of 17α,21-Dihydroxypregn-4-ene-3,20-dione-17-valerate |
| WU Qing-an1,2, WU Hong-wei1, BAI Ting2 |
| 1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China;2. Shanghai New Hualian Pharmaceutical Company Limited, Shanghai 201400, China |
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Abstract The intermediate of hydrocortisone, 17α,21-dihydroxypregn-4-ene-3,20-dione-17-valerate, was synthesized by a seven-step reaction of addition, silicon etherification, cycloaddition-protiodesilylation and so on, using androstendione as the starting material. The total yield was about 75% and purity was more than 96%. The structure was confirmed by 1H NMR and ESI-MS.
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Received: 07 January 2015
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2016, Vol. 24 
