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| Synthesis and Antifungal Activities of Novel Acrylpimaric Acid-based Dithiadiazole Compounds |
| CEN Bo1, WEI You-jie1, DUAN Wen-gui1, LIN Gui-shan1, LIU Lu-zhi1, YANG Zhang-qi2 |
| 1. College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China; 2. Guangxi Academy of Forestry, Nanning 530002, China |
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Abstract Acrylpimaric acid(1) was synthesized by Diels-Alder cycloaddition reaction of rosin with acrylic acid, then converted to its dichloride(2). Eight novel acrylpimaric acid-based dithiadiazole compounds(4a~4h) were synthesized by N-acylation reaction of 2 with 2-amino-5-substituted phenyl-1,3,4-thiadiazoles. The structures were characterized by 1H NMR, 13C NMR, IR and elemental analysis. Antifungal activities tests showed that inhibition rates of 4d(R=m-Cl) against Physalospora piricola, Cercospora arachidicola and Fusarium graminearum were 66.9%, 57.8% and 52.9%, respectively, at 50 μg·mL-1.
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Received: 03 February 2015
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2016, Vol. 24 
