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| Synthesis of 5-Substituted-2,3-dihydro-1H-［1,4］diazepine Compounds |
| CHEN Qi-fan1, ZHANG Hui-dong1, WU Xiao-yan1,2, LIU Fei1 |
| 1. School of Chemical Engineering, Eastern Liaoning University, Dandong 118003, China; 2. College of Chemistry， Northeast Normal University， Changchun 110004, China |
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Abstract Seven 5-substituted-2,3-dihydro-1H-［1,4］diazepine compounds(3a～3g, 3a~3d were novel compounds) were synthesized by Michael nucleophilic addition reaction of enaminone（1） with ethylene diamine（2） in ethanol. The structures were characterized by 1H NMR， IR and elemental analysis． The yields of 3a～3g were 70.0％～74.2％ under the optimum reaction conditions［1 30 mmol, n（2）: n(1)＝1.2, reflux 8 h~10 h, absolute alcohol as recrystallization solvent］.
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Received: 31 August 2015
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2015, Vol. 23 
