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| Synthesis of Novel α-Aminophosohonate Derivatives Containing 6-(4-Aminophenyl)-4,5-dihydro-3(2H)pyridazinone |
| JU Zhi-yu, NIU Liang-feng, LI Fu-yuan, LI Gong-chun, WU Chang-zheng |
| College of Chemistry and Chemical Engineering, Xuchang University, Xuchang 461000, China |
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Abstract Five novel α-aminophosohonate derivatives containing 6-(4-aminophenyl)-4,5-dihydro-3(2H)pyridazinone were synthesized by Mannichtype reaction of aromatic aldehyde, diethyl phosphite and 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone, which was prepared by Friedel-Crafts acylation, amide hydrolysis and condensation, using acetylaniline and succinic anhydride as starting materials. The structures were characterized by 1H NMR, 13C NMR, 31P NMR, IR and ES-MS
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Received: 24 June 2015
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2015, Vol. 23 
