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| Synthesis and Crystal Structure of 2-(N-cyclohexylamine)-6-trifluoromethoxy-benzothiazole |
| WU Xiang-long, LIU Liu, LI You-jia, LUO Jie,GAI Dong-wei, MA Jing-chuan, MEI Qi-bing |
| Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072, China |
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Abstract Riluzole was firstly transformed into (6-trifluoromethoxy-benzothiazol-2-yl)-hydrazine, then was chloridized by SOCl2 to obtain 2-chloro-6-trifluoromethoxybenzothiazole(3). The novel compound, 2-(N-cyclohexylamine)-6-trifluoromethoxybenzothiazole(4), was synthesized by substitution reaction of 3 with cyclohexylamine. The structure was characterized by 1H NMR, IR, elemental analysis and X-ray single crystal diffraction. 4(CCDC： 1 440 686) belongs to triclinic system, space group P-1 with a=10.617(3) ， b=13.607(4) ， c=16.619(5) ， V=2 201.8 3， Dc=1.422 g·cm-3， Z=6， R1=0.082 0， wR2=0.235 1.
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Received: 16 December 2015
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2016, Vol. 24 
