|
|
|
| Organocatalytic Asymmetric Michael Addition of Barbituric Acid to β-Nitroalkenes |
| GUI Yong-yuan1,2, LIU Kang-qiong3, WANG Xiao1,2, TIAN Fang2, PENG Lin2, WANG Li-xin2 |
| 1. University of Chinese Academy of Sciences, Beijing 100039, China; 2. Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China; 3. Sichuan Chenguang Engineering Design Institute, Chengdu 610041, China |
|
|
|
|
Abstract Organocatalytic asymmetric Michael addition of 1,3-dimethylbarbituric acid to β-nitroalkenes was studied using chiral squaric amide as the catalyst. The influence of substrate structure on the enantioselectivity of the reaction was investigated. The addition products were obtained in high yields (80%~100%) and moderate to good enantioselectivity (ee 43%~90%). The structures were characterized by 1H NMR and 13C NMR.
|
|
Received: 29 April 2015
|
|
|
|
|
|
|
2016, Vol. 24 
