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| A New Synthetic Method of α-Sulfo-β-amino Acid Esters |
| HU Xiao-yan1,2, HU Fang-zhi1,2, YUAN Wei-cheng1, ZHANG Xiao-mei1 |
| 1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China; 2. University of Chinese Academy of Sciences, Beijing 100049, China |
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Abstract Five novel α-sulfo-β-enamioesters(3a~3e) were synthesized by oxidative coupling reaction of β-enamioesters and N-(thio)succinimide, using CuBr2 as the catalyst. Then they were hydrosilylated to afford five α-sulfo-β-amino acid moieties(4a~4e). The structures were characterized by 1H NMR. Under the optimized reaction conditions(3 0.1 mmol， HSiCl3 2.0 eq., DCE 1 mL， at room temperature for 12 h), the yield of 4a was 97%.
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Received: 20 April 2015
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2016, Vol. 24 
