新型2-取代氨基-3-氟-4-吡啶氟硼酸钾盐的合成

doi:10.15952/j.cnki.cjsc.1005-1511.2016.04.15146

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Abstract 2-Substituted-amino-3-fluoropyridine compounds(2a~2g) were synthesized by substitution and reduction from 2,3-difluoro-5-chloropyridine. A series of pyridine boric acid compounds(3a~3g)were obtained by reaction of 2 with n-butyllithium and triisopropyl borate. Finally， seven novel potassium(3-fluoro-2-amino substituted pyridin-4-yltrifluoroborates) were synthesized by substitution of 3a~3g with potassium hydrogen fluoride， respectively． The structures were characterized by ¹H NMR, ¹³C NMR, IR, ESI-MS and elemental analysis.

Key words： 5-chloro-2,3-difluoropyridine potassium(3-fluoro-2-amino substitutedpyridin-4-yltrifluoroborate) synthesis

Received: 10 March 2014

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	Articles by authors
	TENG Ming-gang
	ZHAO Chun-shen
	DUAN Lian
	CHAI Hui-fang

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TENG Ming-gang,ZHAO Chun-shen,DUAN Lian, et al. Synthesis of Novel Potassium(3-fluoro-2-amino-substituted pyridin-4-yltrifluoroborates)[J]. Chinese Journal of Synthetic Chemistry, 2016, 24(4): 316-320.

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http://www.hchxcioc.com/EN/10.15952/j.cnki.cjsc.1005-1511.2016.04.15146 OR http://www.hchxcioc.com/EN/Y2016/V24/I4/316

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