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| Synthesis of Novel Choline Derivatives and Their in vitro Antimalarial Activities |
| WANG Fang, ZHAO Qing, CHEN Hui-fang, ZHANG Shu-qiu |
| College of Pharmacy, Shanxi Medical University, Taiyuan 030001,China |
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Abstract Six novel choline derivatives of quaternary ammonium salts(3a~3f) were synthesized by reaction of N,N-dimethyl ethanolamine or N,N-diethyl ethanolamine with brominated alkanes of different carbon chain length under reflux condition. The structures were characterized by UV-Vis， 1H NMR and HR-MS. The antimalarial activities test showed that 3a~3f demonstrated different degrees of inhibiting effect on the growth of plasmodium falciparum 3D7 in vitro, and (1-hydroxy) diethyl -n-butyl ammonium bromide(3f) exhibited the strongest antimalarial activity with IC50 of (68.1±6.5) nmol·L-1, but lower than Artemisinin［IC50(5.7±1.54）nmol·L-1］.
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Received: 28 December 2015
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2016, Vol. 24 
