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| Synthesis and Anti-platelet Aggregation Activities of Novel Thienopyridine Derivatives |
| FAN Meng-lin1,2, JIANG Xi-ming3, LIU Ying2, LIU Deng-ke2, WANG Ping-bao2 |
| 1. Graduate School, Tianjin Medical University, Tianjin 300070, China; 2. Tianjin Institute of Pharmaceutical Limited Co.,Ltd., Tianjin 300193, China; 3. Tianjin Pharmacn Medical Technology Limited Company, Tianjin 300193, China |
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Abstract Novel thienopyridine derivatives(3b~3e, 3g and 5a~5g) were synthesized by substitution reaction of tetrahydrothieno［3,2-c］pyridine or tetrahydrothieno［2,3-c］pyridine with substituted benzyl bromides, and salt forming reaction with ethereal hydrochloric acid. Novel thienopyridine derivatives(7d, 7e, 7g~7i) were synthesized by substitution reaction of tetrahydrothieno［3,2-c］pyridone with substituted benzyl bromides, and condensation with acetic anhydride, then salt forming with 2 mol·L-1 ethereal hydrochloric acid. The structures were characterized by 1H NMR and ESI-MS. The results in platelet aggregation inhibition tests in vivo showed that the compounds exhibited certain activities, 7d, 7h and 7i showed better activities than the positive control drug ticlopidine, and the inhibitory rate were 66.2%, 86.8% and 88.3%, respectively.
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Received: 30 November 2015
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2016, Vol. 24 
