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Synthesis of N-(2-chloroethyl)-N′-2-(O6-benzyl-9-guanineyl)ethyl-N-nitrosourea |
| WANG Ya-meng, REN Ting, SONG Xiu-qing, ZHAO Li-jiao, ZHONG Ru-gang |
| Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China |
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Abstract N-9-(2-amino)ethyl-O6-benzylguanine(4) was obtained through substitution and Gabriel reaction, using O6-benzylguanine as the starting material. N-(2chloroethyl)-N′-2-(O6-benzyl-9-guanine)ethyl-N-nitrosourea(6) was synthesized by isocyanate substitution of 4, followed by a nitrosation reaction. 4 and 6 were new compounds. And their structures were characterized by UV- Vis, 1H NMR, 13C NMR, IR and HR-ESI-MS.
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Received: 24 March 2015
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2016, Vol. 24 
