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| Synthesis of Phloretamide and Its Derivatives and Their Antioxidant Activities |
| WU Dong-dong， FAN Zhi-qiang, REN Jie, HU Kun |
| School of Pharmaceutical and Life Sciences, Changzhou University, Changzhou 213164, China |
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Abstract A series of Phloretamide derivatives were designed and synthesized using 3-(4-hydroxyphenyl)propan-amide as the lead compound. They were synthesized by amidation reaction， using cinnamon acids as the raw materials. 3-(3,4,5-trihydroxyphenyl)acrylamide(2f), 3-(2,3,4-trihydroxyphenyl) propanamide(3e) and 3-(3,4,5-trihydroxyphenyl) propanamide(3f) are new compounds. The structures were characterized by 1H NMR, 13C NMR and ESI-MS. The antioxidant activities of these compounds were investigated. The results showed that 3-(3,4-dihydroxyphenyl)acrylamide(2b), 3-(3,4,5-trihydroxy-phenyl)acryl-amide(2f) and 3-(3,4,5-trihydroxyphenyl)propanamide(3f) had good antioxidant activities with radical scavenging ratio of 66.8%, 59.8% and 69.4% at 10 μmol·L-1, respectively， better than caffeic acid, caffeic acid phenethyl ester and Vc.
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Received: 03 April 2015
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2016, Vol. 24 
