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| Synthesis of Impurity of Fosfluconazole——2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-(4H-1,2,4-triazol-4-yl)propan-2-yl Dihydrogen Phosphate |
| ZHANG You-guo, LI Qiang, HUANG Yi,ZHENG Ren-lin, YUAN Xiao-hong, LI Liang-chun |
| School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China |
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Abstract The main impurity of Fosfluconazole, 2-(2,4-difluoro-Phenyl)-1-(1H-1,2,4-triazol-1-yl)-3-(4H-1,2,4-triazol-4-yl)propan-2-yl dihydrogen phosphateoxalate with purity of 98% and total yield of 7.8%, was synthesized by a seven-step reaction of Friedel－Crafts reaction, nucleophilic substitution, Corey－Chaykovsky reaction, phosphorylation and catalytic hydrogenation, using 1,3-difluorobenzene as starting material. The structure was confirmed by 1H NMR.
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Received: 04 November 2015
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| Cite this article: |
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ZHANG You-guo,LI Qiang,HUANG Yi, et al. Synthesis of Impurity of Fosfluconazole——2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-(4H-1,2,4-triazol-4-yl)propan-2-yl Dihydrogen Phosphate[J]. Chinese Journal of Synthetic Chemistry, 2016, 24(2): 170-173.
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| URL: |
| http://www.hchxcioc.com/EN/10.15952/j.cnki.cjsc.1005-1511.2016.02.15370 OR http://www.hchxcioc.com/EN/Y2016/V24/I2/170 |
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2016, Vol. 24 
