|
|
|
| Synthesis of Polysubstituted β-Carboline by Improved Cadogan Reaction |
| ZHONG Zheng, WANG Xin-ling, FENG Wei-sheng, YANG Huai-xia, ZHANG Jing-yu， SUN De-mei |
| School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China |
|
|
|
|
Abstract Five polysubstituted β-carbolines(3a~3e) were synthesized by improved Cadogan reaction, using phenylnitro pyridine(2a~2e) as precursors, P(Ph)3 as reductant and DMAc as solvent. The structures were confirmed by 1H NMR and HR-ESI-MS. The yields of 3a~3e were 45%~85%, under the optimized conditions［2 4 mmol, PPh3 10 mmol, DMAc 5 mL, reacted at 170 ℃ for 16 h］, respectively.
|
|
Received: 25 September 2015
|
|
|
|
|
|
|
2016, Vol. 24 
