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| Synthesis and Cytotoxicity of A Novel O6-benzylguanine Derivative |
| LI Si-si1, PENG Rui-zeng2 |
| 1. Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China; 2. College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China |
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Abstract A novel O6-benzylguanine(O6-BG) derivative, 4-nitrobenzyl-［6-(benzyloxy)-9H-purin-2-yl］carbamate(4), was synthesized by a four-step reaction, using O6-BG as starting material. The structure was characterized by 1H NMR and HR-ESI-MS. The cytotoxicities of 4 were investigated by CCK-8 method. The results indicated that 4 exhibited better inhibition activities against human glioma cell lines(SF126, SF763 and SF767) with ACUN than O6-BG under hypoxia conditions. IC50 of 4 against SF126, SF763 and SF767 were 0.04 mM, 0.1 mM and 0.03 mM, respectively.
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Received: 16 March 2015
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2016, Vol. 24 
